I am a passionate researcher with a wide-ranging research experience. As an undergraduate student in Italy, I sequenced the sunflower mitochondrial DNA and during my PhD, I characterized thyroid-specific transcription factors. I studied the dopaminergic system during my first postdoctoral experience at the IGBMC in Strasbourg, France. During these early years, I was highly productive. However, my fruitful experiences helped me realize Science is not about publications. The real excitement is to investigate the unknown, to make original discoveries. Research that aims at incremental discoveries may be easier but it is certainly not exciting. I had the opportunity to test myself during my second postdoctoral training (Johns Hopkins in Baltimore, USA). My project was centered on understanding the biological role of inositol pyrophosphates (PP-IPs). In one year I managed to biochemically purify the enzymatic activity from rat brain and to clone the inositol hexakisphosphate kinase (named IP6K), thereby opening a new scientific field.
In summer of 2004, I moved to London to establish my independent laboratory. My laboratory mainly studies cell signaling events mediated by PP-IPs and has substantially contributed to the establishment of this class of molecules as fundamental cellular messengers. We initially proposed, and subsequently provided fundamental evidence, that PP-IPs lie at the interface between cell metabolism and cell signaling, thereby playing a key role in regulating cellular energetics. To understand how PP-IPs regulate basic metabolism we have focused our attention on phosphate homeostasis discovering that PP-IPs regulate the metabolism of inorganic polyphosphates (polyP) the linear chain of phosphate. This was an innovative and highly influential concept that we helped to establish.
Another strength of my laboratory is based on my strongly believe that the generation of new analytical methods represents a fundamental aspect of scientific innovations, Therefore, my laboratory has contributed a number of technological advances that have been instrumental in propelling PP-IPs into mainstream research. For example, the PP-IPs PAGE analysis allows the detection of these molecules by simple toluidine staining. The new TiO2 based inositol phosphates purification protocol we developed is opening previously unforeseen research opportunities in my lab and elsewhere around the world.
Finally, I strongly believe that science is an open enterprise and my laboratory freely shares published and unpublished data, protocols, tools, and reagents. This attitude together with our distinctive theoretical and technical expertise has contributed to the high standing achieved by my research group.
I am the Communications and Digital Platforms Associate at FEBS, and I help manage content and use of online platforms and sites such as the FEBS Network, FEBS website and FEBS Congress website, but particularly on the FEBS Network. Previously I have managed the funding programmes of a number of UK research charities, mainly in the field of cancer. I have supported the income generation teams at those organisations with science communication, as well as developed e-learning resources for staff and students at the Institute of Cancer Research. I have a BSc in Biochemistry, an MSc in Nutrition and a Postgraduate Diploma in Dietetics. After years in London I have now moved back to Spain, where I continue to work as a science communicator.
I am an Associate Professor at the Department of Biochemistry and Clinical Analysis at the Faculty of Pharmacy, University of Sarajevo. My research interest in general is the area of genetics of type 2 diabetes, obesity and metabolic syndrome, pharmacogenetics of diabetes, association of inflammatory biomarkers and free fatty acids with diabetes, obesity and metabolic syndrome.
Subham Preetam is a professional biotechnologist who collaborates with a creative bio-robotics researcher. His area of expertise lies in early-stage research in biomedical robotics engineering, with a particular interest in quantum engineering for the manufacturing of bio-hybrid robots. He is dedicated to the advancement of precision medicine and successful preclinical research to enhance the quality of life for individuals.
With extensive cross-disciplinary training and experience in translational research, Mr. Preetam is currently focused on various research topics, including micro-robotics, soft bio-hybrid robots, and quantum nanorobot fabrication for removing heavy metals from ocean water. His research aims to improve the life expectancy of sea animals and humans.
Furthermore, he is involved in developing a bio-fluidics nanomedicine system that leverages the latest drug delivery technologies to create personalized solutions for brain cancer patients in South Korea and Sweden. Additionally, he collaborates with researchers from India, Taiwan, Israel, Saudi Arabia, the US, China, Denmark, Singapore, Spain, Portugal, and the United Kingdom on various collaborative projects.