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Sigrid Jusélius Senior researcher, Associate Professor (Docent) of biochemistry
PI at Faculty of Medicine, University of Helsinki, Finland
Author of 139 peer reviewed articles (cited 4095 times), h-index 39 (web of Science)
Chair of the Biobio Society and Finnish National Committee for Biosciences
Orcid ID: orcid.org/0000-0003-0926-3109
I have a title of docent (associate professor) of biochemistry and since 2009 have been a PI in the Faculty of Medicine, Univ. of Helsinki. After receiving my D.Sc. degree in 2000, I worked for two years as a Marie Curie Industrial Host fellow at GlaxoSmithKline, UK. From 2004 I have worked at the Dept of Clinical Chemistry and Haematology, Univ. of Helsinki, which includes a five-year period as an Academy Research Fellow. Currently I work as a Sigrid Jusélius senior researcher, allowing me to concentrate on research projects.
In my doctoral thesis I identified diverse tissue specific glycoforms of glycodelin. Our findings demonstrated that the glycodelin represents one of the foremost examples of how glycosylation dictates the function of a glycoprotein. More recently my group went on to show that glycodelin is differentially glycosylated in endometrial cancer cells and it differentiates these cells towards a less aggressive phenotype, resulting in reduced tumor growth in a preclinical animal model.
For the last 20 years my main focus has been on the functions and diagnostic potential of proteases in cancer, especially prostate cancer. These studies involve development of novel patient-derived cell/tissue models to better recapitulate prostate cancer. In an international collaborative effort, which I coordinated, we developed PSA stimulators and KLK2 inhibitors, aiming to slow down prostate cancer growth. Currently my group and collaborators are developing trypsin-3 inhibitors for targeting cancer metastasis.
My work has been published in journals like Nature Chemical Biology, Endocrine Reviews, Journal of Clinical Investigation, Blood, Cancer Research and Environmental Health Perspectives.
In addition to basic research experience, I have research experience in pharmaceutical industry from my postdoctoral period at GlaxoSmithKline, UK. This exposure to the drug discovery process will be helpful when research innovations are translated to the benefit of patients.
Education of postgraduate students including supervision of PhD projects and organization of student seminars and international symposia have been an integral part of my academic life. I feel that scientists have the responsibility to communicate science to a wider audience. For that purpose, I have taken on the role of Chairman of the Biobio-society. I am also the Chairman of the Finnish National Committee for Biosciences, which presents Finnish biosciences internationally.
The International Union of Biochemistry and Molecular Biology unites scientists in 75 countries or regions through a society, national council, or academy of sciences.
FEBS Letters is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Reviews, Research Letters and Research Articles that merit urgent publication.
Societas biochemica, biophysica et microbiologica Fenniae, the Biobio Society, is a scientific society that promotes biochemical, biophysical, microbiological and related biological research in Finland.
Guilherme G. Moreira is a PhD Student at Protein Misfolding and Amyloids in Biomedicine (PMAB) group (http://folding.fc.ul.pt) at Faculty of Sciences of the University of Lisbon and affiliated to BioISI Biosystems & Integrative Sciences Institute. Born in 1995, has graduated in Biochemistry (2016) and completed his master's in Medical Biochemistry (2018) at the University of Lisbon. Guilherme started his PhD studies with an FCT PhD Studentship on the PMAB GomesLab (2021) with the project entitled The calcium-binding protein S100B as a novel chaperone preventing Tau aggregation in Alzheimer's disease. Guilherme is the first author of 3 published peer-reviewed international papers (2019, 2021 and 2023), co-author of 1 published book chapter (2020) and co-author of 2 published peer-reviewed international paper (2021 and 2022), as well as author of 19 posters and 5 oral communications presented in national and international events. Has been awarded 6 travel/accommodation and registration awards for international meetings.
Research Identifiers
Google Scholar: https://scholar.google.com/citations?user=https://scholar.google.com/citations?user=BTcYDiYAAAAJ&hl=pt-PT&user=BTcYDiYAAAAJ
Scopus: https://www.scopus.com/authid/detail.uri?authorId=57212030809
ORCID: https://orcid.org/0000-0003-4791-5403
Web Of Science: https://www.webofscience.com/wos/author/record/B-6154-2018
Daria Navrotska
Researcher, Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine
Alberto Gomez-Navarro
Early Stage Researcher, LENS - European Laboratory for Non-Linear Spectroscopy
I have Biochemistry BSc education and had my MSc degree in Medical Biochemistry. I have gained my PhD degree on Medical Biology and Genetics. I have research experience in biochemistry, cancer biology, and tumor genetics. Most recently became a member of ISUMKAM research group at Istinye University.
António José de Jesus Matos Figueira
PhD Student, Faculdade de Ciências da Universidade de Lisboa
Zane Kalnina
Leading researcher, Associate Professor, Latvian Biomedical Research and Study center, University of Latvia
The FEBS Junior Section is organised by students and young researchers from some FEBS Constituent Societies. They develop joint activities, such as online talks and other events, and share resources, as well as open doors for young European scientists to opportunities outside their home countries by providing the relevant contacts and fostering communication within the network.