I am a Professor of Toxicology, Biochemistry and Cell Signaling at Université Paris Cité (former Université Paris Descartes). I have completed my PhD in molecular toxicology and a post-graduate year in Bethesda, MD. I am the head of a Master degrees in toxicology and ecotoxicology. My research is based on cellular and animal models and on three main axes: 1) the influence of persistent organic pollutants on breast tumorigenesis and metabolic disruption, 2) the contextual role of pollutants in the occurrence of chronic liver diseases including steatosis and fibrosis, 3) the effect of mixtures on the progression of neurodegenerative diseases. I am involved in the development of innovative pedagogy methods and technics in order to improve transmission, acquisition, memorization and utilization of scientific knowledge by our biomedical students. I used flipped classrooms, quizzes (at home and during courses) and virtual reality to interact and immerge with students in and outside the classroom. Indeed, I developed with pedagogic engineers, 1) Home-based 45’’ Quizzes to engage students in regular learning modes and 2) serious games on cell signaling and xenobiotic stress. Together, with Etienne Blanc, Caroline Chauvet and Frédéric Dardel, I wrote several French books of biochemistry and toxicology topics for undergraduate students. I collaborate with several national and international institutes and universities (CNAM Thierry KOSCIELNIAK, Université de Strasbourg Jean-Luc SOUCIET, National University of Singapore, Fun Man FUNG...) for the development of innovative methods in teaching.

neuroscience; nanotechnology; nanotoxicology; space biology

Biochemistry, molecular biology, animal models, cell organelles, liver fibrosis New methods in bioscience education

Regulation of Gene Transcription Internationalisation (International Students)

Compositiona and metabolism of bone. Testing the pharmaceutical potential of new chemical compounds.

EXPERTISE FOR TEACHING

Matrix Pathobiology, Extracellular Matrix, Matrix-mediated cell regulation and singaling, Pharmacological targeting, Biochemical Assays, Proteoglycans, Glycosaminoglycans, Metalloproteinases

Protein biochemistry and biophysics Amyloids Enzymology

Bioinformatics

Expertise in teaching. Using interactive videos in teaching. Flipped classroom. Digital exams. Team Based Learning in biochemistry.

I spent 40 years teaching and researching, and developed a particular interest in education and career development. I chaired the Education Committee and was Careers advisor for the UK Biochemical Society. In these roles, and my work with students at the University of Manchester, I realised how important it is for young scientists to recognise their skills and be able to "sell" themselves to potential employers (and grant awarding bodies). I now run CV support sessions for young scientists on behalf of the FEBS Education Committee, of which I was a founder member.