Dr. Inmaculada Yruela graduated and earned her doctorate in Chemistry at the University of Sevilla (Spain). She has been a visiting guest scientist at the Max Planck Institute for Chemical Energy Conversion in Mülheim an der Ruhr (Germany) and at Department of Biochemistry and Molecular Biology in Indiana University School of Medicine (USA). She is research scientist at the CSIC and group leader at Computational and Structural Biology in Estación Experimental de Aula (CSIC), Zaragoza (Spain). From the early 1990s she has been studying the relationship between the structure and function of redox protein complexes involved in photosynthesis (I.e. PSII, cytochromes) among other, and more recently the role of intrinsic ductiliity and plasticity of proteins in organismal complexity, multicellularity and evolution. She has led science outreach projects. She is currently member of SEBBM.
Our lab uses genetically modified mouse models and a combination of cell biology, molecular biology, and biochemistry techniques to study the role of altered mitochondrial dysfunction and metabolism in human diseases. A primary analytical tool of the group is metabolomics, which enables the parallel quantification of hundreds of small molecule metabolites. The team also uses computational approaches to integrate datasets from multi-dimensional analyses, including metabolomics, proteomics, and transcriptomics, with the aim to model aging-related disorders and to generate mechanistic hypotheses that will be cross validated experimentally.