Young NVBMB/FEBS Junior Sections present Tessa Sinnige

The third talk of 2022 from the FEBS Junior Sections initiative is organized by Young NVBMB, the Junior Section of the Dutch Society. Dr Tessa Sinnige, from Utrecht University, will talk about the molecular mechanisms of protein aggregation on 10 March at 19:00 (CET). Please help us share this post!
Young NVBMB/FEBS Junior Sections present Tessa Sinnige
Like

Update! Watch the recording of this talk.

This talk is an activity from the FEBS Junior Sections, an initiative set up by students and young researchers from some of the FEBS Constituent Societies. Each month a junior section from one of the participant Societies organizes an online event on either a research or a career topic. This March talk is organised by Young NVBMB, the junior section of the NVBMB.

Speaker: Dr Tessa Sinnige, Utrecht University, The Netherlands
Topic: “Elucidating the molecular mechanisms of protein aggregation in C. elegans as a living model system”
Time: 10 March 2022, 19:00 (CET)
Registration: https://us02web.zoom.us/webinar/register/WN_ocw-HlvYSiucY7FoelPBsw
(NVBMB will approve the registration request and send you a meeting link)
For more information, see the presentation abstract below and visit the Sinnige lab website.

Abstract

Proteins are the molecular machines of the living cell, and need to fold into their correct three-dimensional conformations in order to function. However, proteins may also misfold into non-functional and potentially hazardous structures. Amyloid fibrils are a prime class of non-native protein assemblies that accumulate as insoluble aggregates in a wide variety of human disorders, including Alzheimer’s, Huntington’s and Parkinson’s diseases. The process of fibril formation has been studied in molecular detail using kinetic studies on purified proteins. However, it is not yet clear to what extent the biophysical principles of amyloid formation established in these studies translate to the complex environment of living cells and organisms. In my lab, we use the nematode C. elegans as a model system to investigate the molecular mechanisms of protein aggregation in a living and ageing animal. In my talk, I will present recent work on the kinetic analysis of polyglutamine, which is associated with Huntington’s and other polyglutamine expansion diseases.

The FEBS Junior Sections

Want to join this platform for young European life scientists?  Learn more about our initiative, check out the Room for Junior Sections of FEBS Societies and – if you do not have a junior section yet – read this post about how to set one up!

If you have registered to receive emails about FEBS Junior Sections events and would like to unsubscribe, please use this form. If you have any problems with the form, contact info@febs.org


Photo by Milad Fakurian on Unsplash 

Join the FEBS Network today

Joining the FEBS Network’s molecular life sciences community enables you to access special content on the site, present your profile, 'follow' contributors, 'comment' on and 'like' content, post your own content, and set up a tailored email digest for updates.