Update! Watch the recording of this talk.
This talk is an activity from the FEBS Junior Section, an initiative set up by students and young researchers from some of the FEBS Constituent Societies. Each month a Junior Section from one of the participant Societies organizes an online event on either a research or a career topic. This March talk is organised by Young NVBMB, the junior section of the NVBMB.
Speaker: Dr Tessa Sinnige, Utrecht University, The Netherlands
Topic: “Elucidating the molecular mechanisms of protein aggregation in C. elegans as a living model system”
Time: 10 March 2022, 19:00 (CET)
For more information, see the presentation abstract below and visit the Sinnige lab website.
Proteins are the molecular machines of the living cell, and need to fold into their correct three-dimensional conformations in order to function. However, proteins may also misfold into non-functional and potentially hazardous structures. Amyloid fibrils are a prime class of non-native protein assemblies that accumulate as insoluble aggregates in a wide variety of human disorders, including Alzheimer’s, Huntington’s and Parkinson’s diseases. The process of fibril formation has been studied in molecular detail using kinetic studies on purified proteins. However, it is not yet clear to what extent the biophysical principles of amyloid formation established in these studies translate to the complex environment of living cells and organisms. In my lab, we use the nematode C. elegans as a model system to investigate the molecular mechanisms of protein aggregation in a living and ageing animal. In my talk, I will present recent work on the kinetic analysis of polyglutamine, which is associated with Huntington’s and other polyglutamine expansion diseases.
The FEBS Junior Section
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Photo by Milad Fakurian on Unsplash
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