World Cancer Day at The FEBS Journal

#WorldCancerDay, celebrated yearly on 4th February, aims to raise awareness and to celebrate scientific and clinical progress. The FEBS Journal marks the occasion with a dedicated collection of free-to-read articles in our latest issue.
World Cancer Day at The FEBS Journal
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The latest issue of The FEBS Journal is now available online. Whilst a new issue lands, like clockwork, every two weeks, this one is a little special. Alongside the usual bounty of research papers describing the latest developments in the molecular life sciences, the issue features a cancer-focused front half. 

Two protein structures side by side showing the open and closed conformation of a sugar transporter in a marine bacterium. Above the schematic, the title 'The FEBS Journal' and the caption 'Structural basis of chitin recognition in a marine bacterium' appear in white font on a black background.

First up, meet Editorial Board Member, Dr Daniel Longley. The focus of Daniel's research group is to investigate how cancer cells survive treatment - a theme that perfectly aligns with #WorldCancerDay. In his Editor Profile interview, he talks about the scientific breakthroughs that excite him the most, the challenges of finding balance in busy academia, and how he came to join our Editorial Board. We found our chat with Daniel delightful, and hope you will, too!

For those who crave more, we highlight a new State-of-the-Art Review: Serge Manie and team summarise the latest in in vitro modelling of cancer metabolism. Modelling technologies are advancing at lightning speed and, despite remaining rather reductionist, allow researchers to ask increasingly sophisticated questions. Learn more in this brilliant free-to-read article.

Following on the theme of cancer metabolism, a Review by Xiang Li and Hong-Sheng Zhang discusses amino acid metabolism in cancer cells and explores the pivotal role of this process in epigenetic regulation and stress response. This article is also free to read and share with your colleagues!

Black-and-white scanning electron microscopy image of colorectal cancer cells grown in artificial extracellular matrix. Left: Matrigel-only, cells are more round. Right: Matrigel with collagen fibrils, cells acquire a spindle-like morphology.
The major extracellular matrix component collagen affects colorectal cancer cell phenotypes.
Image adapted from Franchi et al., 2023. For permissions, see https://doi.org/10.1111/febs.16938

We close our cancer-focussed bundle with a Viewpoint article, written by Editorial Board Member Nikos Karamanos and his team. This Open Access article discusses how the varied biomechanical properties of the extracellular matrix affect tissues in health and disease. Studies over the past few decades have indeed uncovered that the matrix is far from inert when it comes to cancer - the cancer extracellular matrix itself, and the cells that deposit it, cancer-associated fibroblasts, are crucial players in cancer cells' development, growth, spread and response to treatment. 

We hope you enjoy these articles. Feel free to share them with your colleagues. The FEBS Journal is grateful to all our authors, reviewers and editors who work in cancer research. 


Top image by Franchi et al., 2023. For permissions, see https://doi.org/10.1111/febs.16938

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