In this issue's ‘hidden gems’, Manuel Breuer summarisies previous review and research article content:
1) Roy et al. investigate the wild‐type version of the huntingtin gene product in their Editor's Choice article.
2) In a second Editor's Choice article, Zhou et al. identify the E3 ubiquitin ligase TNF receptor‐associated factor 2 (TRAF2) as an interactor of the core clock protein BMAL1.
3) A State‐of‐the‐Art review by MacPherson et al. discusses how the knowledge of metabolic programmes during lymphocyte differentiation could be used for T‐cell therapy.
4) A second State‐of‐the‐Art review from Fennell et al., sheds light on the manifold types of ubiquitination of protein substrates and the recognition of ubiquitinated substrates by ubiquitin‐binding domains (UBD) for downstream signalling cascades.