Our interviewee is Tristan Samuels, a PhD Candidate in the Department of Biochemistry at Western University in London, Ontario, CA. Tristan received a FEBS Open Bio Poster Prize at the FEBS special meeting: expanding frontiers in aminoacyl-tRNA synthetase research, held from 28 September to 3 October 2025, in Dubrovnik, Croatia.

Tell us about your research topic/work. What project(s) are you working on? What is the aim of your study?

Our laboratory is interested in elucidating the cellular and molecular mechanisms of pathogenic variants in aminoacyl-tRNA synthetases using model systems such as yeast. We also look to employ cognate substrate supplementation as a treatment strategy to rescue observed defects, which hopefully can eventually be translated as a therapeutic for real patients. I am currently working on various NARS1-disease- causing variants in the cytoplasmic asparaginyl tRNA- synthease, as well as some dominant Charcot-Marie Tooth disease (CMT)-associated variants in the cytoplasmic tyrosyl-tRNA synthetase.

Who or what inspired you to choose a career in science?

I had a great experience volunteering in a translational health outcomes research lab during my undergraduate studies, which served as my proper introduction to research. This experience made me realize how I enjoyed employing the scientific method to answer questions. However, there was not much of a wet lab component, which I wished to experience, and was offered by the lab that I now find myself in!

How does it feel to receive a FEBS Open Bio Poster Prize as recognition for your work? How do you see this Prize influencing your career and future plans?

To receive this award was extremely flattering, and validating. As most graduate students do, I have experienced imposter syndrome and doubts about whether or not I deserve to be in the position that I am. Being surrounded by the most prestigious scientists in my niche of research at the AARS special meeting exacerbated this feeling, but receiving this award has helped to reassure me that I am a competent scientist, and others can see that!

What advice would you give to aspiring students/scientists?

Do not be discouraged after setbacks. They are natural in the world of science and serve as a learning opportunity. Dedication and motivation (which stems from your curiosity and interest in your work) will make sure you get over the line, not how 'intelligent' you are!

Where do you envision the future of your career?

The goal is to become a clinician-scientist, although I am open to an industry-related career as well.