Over the past 20 years, I have been interested in cell division and nuclear organization, including systematic analysis of mitosis, nuclear pore complex structure and assembly, as well as chromatin organization and formation and segregation of mitotic and meiotic chromosomes. My goal has been to obtain structural and functional measures of the required molecular machinery inside cells using quantitative 4D imaging, single molecule spectroscopy, as well as light sheet and super-resolution microscopy, which my group is constantly developing and automating to address all molecular components comprehensively. Since many years we are supporting large EU-wide efforts on systems biology of mitosis, as well as microscopy automation and unbiased computational image analysis, (www.mitocheck.org, www.mitosys.org, www.systemsmicroscopy.eu), establishing methods to reliably score up to billions of cells and capture rare and transient functional states automatically.

Due to the importance of new imaging technologies for the future life sciences and to make imaging technologies more accessible to researchers, I have coordinated EMBL 's and European efforts which led to the establishment of the EMBL Imaging Centre (https://www.embl.org/imaging-centre/) and of the Euro-BioImaging ERIC (www.eurobioimaging.eu), respectively.