I am working in cerebrovascular pathophysiology and vascular and cardiac pathology, focusing on the relationship between endothelial cells and metabolic factors.
I am a molecular biophysicist applying single-molecule fluorescence spectroscopy and advanced fluorescence microscopy techniques as well as tailoring new techniques and integrating with other experimental and theoretical techniques to study biomolecular interactions, structure, and dynamics in solution and the cell.
I have been implementing my knowledge and experience in performing experiments to answer questions regarding various biomolecular systems, such as Adenylate Kinase, the bacterial transcription initiation complex, p53, the amyloid-beta peptide, alpha-synuclein, and more.
Since I opened my lab in 2018, I have been interested in the molecular etiology of a group of diseases called Synucleinopathies (e.g., Parkinson's disease).
My interests include, but are not limited to (i) the structure-dynamics-function relationship in intrinsically disordered proteins (IDPs); (ii) phase-separated bio-condensates in health and disease; (iii) sensitive detection of bio-nanoparticles, such as viruses, exosomes, and IDP-based oligomers/aggregates.
Associate Dean for Flexible and Digital Education, Faculty of Biology Medicine and Health Sciences
MSc in Bacterial Physiology and PhD in Protein Biochemistry
Professor (Associate) at Akdeniz University
Structural and functional analysis of rat prolactin receptor gene. Rat prolactin receptor and isoforms in liver and kidney. Non-genotoxic toxicity and tumorigenesis mechanisms of ochratoxin A (OTA) in vivo and in vitro. The role of testosterone and estrogen in OTA toxicity. The receptor mediated OTA toxicity and tumorigenesis in rat kidney.
Ochratoxins
Prolactin Receptors
Estrogen Antagonists
Estrogen Receptor
Testosterone
Androgen Receptors
Nonsteroidal Anti-Androgens
Ovariectomy
Castration
mRNA Expression
Renal Pathology
Renal Cancer
Targeted Drug Delivery
Toxicity
Endocrine Disruption
Reproductive Toxicology
Estrogens
Cancer Biology
Androgens
Steroids
Toxicity Studies
Native PAGE
Endocrine Disruptors
Environmental Toxicology
Animal Physiology
Encapsulation
Cancer Research
Nanoparticles
Microbiology
Biotechnology
Proteins
Protein Stability
Ions
Mycotoxins
Cancer Cell Biology
Fluorescence Spectroscopy
Site-Directed Mutagenesis
Wistar Rats
Protein Folding
Circular Dichroism
Protein Conformation
Cell Culture
Molecular Endocrinology
Neuroendocrinology
Biomarkers
PCR
Protein Purification
Reproductive Endocrinology
Protein Structure
Protein-Protein Interaction
Zane Kalnina
Leading researcher, Associate Professor, Latvian Biomedical Research and Study center, University of Latvia