Special Issue: Senescence in Ageing and Disease

Special Issue: Senescence in Ageing and Disease

Cellular senescence has been shown to be involved in a variety of biological functions, and therefore is considered as a key contributor to a diverse group of processes, ranging from normal physiology, to ageing, and also to disease development.

In this Special Issue of The FEBS Journal on Senescence in Ageing and Disease, you will find an exciting collection of recently published reviews and research articles that focus on the roles of senescence in physiological tissue functions, during the ageing process and in the development of pathological conditions.

Among the topics discussed here is that it has now become clear that senescent cells can have both beneficial and adverse effects following tissue injury. Moreover, through the content of this article collection it is stressed that, while senescent cells are essential for maintaining a healthy physiology, they are also responsible for promoting ageing as well as emergence and progression of various diseases. Recent advances in identifying these cells and new methods to isolate them are overviewed herein.

This Special Issue also features several reviews that discuss the senescence-associated secretory phenotype (SASP), which mediates the inter-organ communication between senescent cells and other cell types present in the microenvironment of different tissues. The role of the SASP in cancer initiation and progression as well as in the emergence of SARS CoV-2 variants is also highlighted.

In one of the two original articles included in the issue, the impact of dietary macronutrients and the presence of senescent cells in mice is investigated. Finally, the use of senolytics and senomorphics to specifically target senescent cells or their secreted components, respectively, is overviewed in several of the reviews included in the issue.

In their introductory Editorial, Darren J. Baker, Masashi Narita and Pura Muñoz-Cánoves expertly summarise the issue’s content, and we encourage you to read it for a comprehensive overview of the aspects of senescence discussed. Many thanks to all the authors for their excellent contributions to this Special Issue on Senescence in Ageing and Disease.


On the cover: Cartoon of ageing cells interacting in an ‘old cells home’. Illustration credited to Neil Smith www.neilsmithillustration.co.uk



  1. Baker DJ, Masashi Narita M & Muñoz-Cánoves P (2023) Cellular senescence: beneficial, harmful, and highly complex. FEBS J. 290, 1156–1160.
  2. Moiseeva V, Cisneros A, Cobos AC, Tarrega AB, Oñate CS, Perdiguero E, Serrano AL & Muñoz‐Cánoves P (2022) Context‐dependent roles of cellular senescence in normal, aged, and disease states. FEBS J. 290, 1161–1185.
  3. Martini H & Passos JF (2022) Cellular senescence: all roads lead to mitochondria. FEBS J. 290, 1186–1202.
  4. Estévez‐Souto, V, Da Silva‐Álvarez S & Collado M (2022) The role of extracellular vesicles in cellular senescence. FEBS J. 290, 1203–1211.
  5. Sheekey E & Narita M (2021) p53 in senescence–it's a marathon not a sprint. FEBS J. 290, 1212–1220.
  6. Harries LW (2022) Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescence. FEBS J. 290, 1221–1234.
  7. Sweeney M, Cook SA & Gil J (2022) Therapeutic opportunities for senolysis in cardiovascular disease. FEBS J. 290, 1235–1255.
  8. Rachmian N & Krizhanovsky V (2022) Senescent cells in the brain and where to find them. FEBS J. 290, 1256–1266.
  9. Sahinyan C, Lazure F, Blackburn DM, Soleimani VD (2022) Decline of regenerative potential of old muscle stem cells: contribution to muscle aging. FEBS J. 290, 1267–1289.
  10. Yasuda T, Baba H, & Ishimoto T. (2021) Cellular senescence in the tumor microenvironment and context‐specific cancer treatment strategies. FEBS J. 290, 1290–1302.
  11. Klein A, Rhinn M & Keyes WM. Cellular Senescence and Developmental Defects. FEBS J. 290, 1303–1313.
  12. Lozano‐Torres B, Blandez JF, García‐Fernández A, Sancenón F & Martínez‐Máñez R (2022) Lipofuscin labelling through biorthogonal strain‐promoted azide‐alkyne cycloaddition for the detection of senescent cells. FEBS J. 290, 1314-1325.
  13. Ng PY, McNeely TL & Baker DJ (2021). Untangling senescent and damage‐associated microglia in the aging and diseased brain. FEBS J. 290, 1326–1339.
  14. Nehme J, Yang D, Altulea A, Varela‐Eirin M, Wang L, Hu S, Wu Y, Togo J, Niu C, Speakman JR & Demaria M (2021) High dietary protein and fat contents exacerbate hepatic senescence and SASP in mice. FEBS J. 290, 1340–1347.
  15. Takasugi M, Yoshida Y, Hara E & Ohtani N (2022) The role of cellular senescence and SASP in tumour microenvironment. FEBS J. 290, 1348–1361.
  16. Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ & Robbins PD (2022) Targeting cellular senescence with senotherapeutics: Senolytics and senomorphics. FEBS J. 290, 1362–1383.
  17. Karakasiliotis I, Lagopati N, Evangelou K & Gorgoulis VGG (2021) Cellular senescence as a source of SARS‐CoV‐2 quasispecies. FEBS J. 290, 1384–1392.

Join the FEBS Network today

Joining the FEBS Network’s molecular life sciences community enables you to access special content on the site, present your profile, 'follow' contributors, 'comment' on and 'like' content, post your own content, and set up a tailored email digest for updates.