IFBA certified professional in BRM, interested in Biosafety, Biosecurity and Bioethics, Research, Molecular Biology, Biostatistics, Autoimmune Diseases, Biotechnology, Molecular Biology

I am a Professor of Toxicology, Biochemistry and Cell Signaling at Université Paris Cité (former Université Paris Descartes). I have completed my PhD in molecular toxicology and a post-graduate year in Bethesda, MD. I am the head of a Master degrees in toxicology and ecotoxicology. My research is based on cellular and animal models and on three main axes: 1) the influence of persistent organic pollutants on breast tumorigenesis and metabolic disruption, 2) the contextual role of pollutants in the occurrence of chronic liver diseases including steatosis and fibrosis, 3) the effect of mixtures on the progression of neurodegenerative diseases. I am involved in the development of innovative pedagogy methods and technics in order to improve transmission, acquisition, memorization and utilization of scientific knowledge by our biomedical students. I used flipped classrooms, quizzes (at home and during courses) and virtual reality to interact and immerge with students in and outside the classroom. Indeed, I developed with pedagogic engineers, 1) Home-based 45’’ Quizzes to engage students in regular learning modes and 2) serious games on cell signaling and xenobiotic stress. Together, with Etienne Blanc, Caroline Chauvet and Frédéric Dardel, I wrote several French books of biochemistry and toxicology topics for undergraduate students. I collaborate with several national and international institutes and universities (CNAM Thierry KOSCIELNIAK, Université de Strasbourg Jean-Luc SOUCIET, National University of Singapore, Fun Man FUNG...) for the development of innovative methods in teaching.

I am an Associate Professor at the Department of Biochemistry and Clinical Analysis at the Faculty of Pharmacy, University of Sarajevo. My research interest in general is the area of genetics of type 2 diabetes, obesity and metabolic syndrome, pharmacogenetics of diabetes, association of inflammatory biomarkers and free fatty acids with diabetes, obesity and metabolic syndrome.

Atherosclerosis, inflammatory diseases, biomarkers

My research activity has mainly concerned pyridoxal phosphate-dependent enzymes and vitamin B6 metabolism in bacteria and humans. Concerning PLP-dependent enzymes, I have dealt with their catalytic mechanism, catalytic promiscuity and evolution of catalytic activities, the design and experimentation of specific inhibitors, the mechanism of addition of PLP to apoenzymes and the folding mechanism. At the moment, I am mainly focused on the regulation of PLP biosynthesis and salvage pathways in bacteria and humans. In particular, I am interested in enzyme regulation mechanisms and transcriptional regulation, in the mechanism of PLP transfer to apoenzymes and in neurological disorders related to PLP metabolism. I teach Biochemistry, Biochemical Methods and Enzymology in Biological Sciences, Industrial Chemistry and Biotechnology courses at Sapienza University.