Special Issue on Redox Medicine

FEBS Letters' new Special Issue highlights the roles of redox regulation of signaling pathways in human physiology and pathology.
Special Issue on Redox Medicine
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This new Special Issue of FEBS Letters, guest-edited by Ana Ledo and Bárbara S. Rocha (University of Coimbra), features eleven reviews that provide an overview of redox signalling, the modulation of molecular pathways by free radicals and oxidants, as an emerging and unifying theme in the pathophysiology of human diseases.

Five reviews explore redox mechanisms of bioenergetic inefficiency and aberrant mitochondrial structure or metabolism. Of these, three focus on brain disease [1] or ageing [2][3], and two focus on redox reprogramming and signaling dysfunction in the context of malignancy [4][5].

Mitochondrial dysfunction is further discussed in the context of age-related physiological decline, with mitochondria explored as targets for improving healthspan [6]. Another review considers both beneficial and detrimental effects of oxidants on insulin action [7].

Two reviews discuss pathophysiological redox-dependent lipid modifications and explore their potential as diagnostic markers and therapeutic targets. Of these, one highlights non-enzymatic oxidation of phospholipids in the context of inflammation [8], and another focuses on ferroptosis and lipid peroxidation in ischemic stroke [9].

A final two reviews consider the modulatory effect of diet on redox pathways in vivo. Of these, one discusses the interaction of dietary (poly)phenols on cell membranes and their effect on eNOS and ACE1 [10], and another proposes redox species as modulators of oral and gut microbiota [11].

FEBS Letters thanks the guest editors for their input and dedication in curating the publication of this excellent issue, and we invite you to read their full editorial.


  1. Di Domenico F, Lanzillotta C and Perluigi M (2024) Redox imbalance and metabolic defects in the context of Alzheimer disease. FEBS Lett doi: 10.1002/1873-3468.14840
  2. Polidori MC (2024) Embracing complexity of (brain) aging. FEBS Lett doi: 10.1002/1873-3468.14941
  3. Santos D, Simão S, Nóbrega C, Bragança J, Castelo-Branco P, Araújo I and ALFA Score Consortium (2024) Oxidative stress and aging: synergies for age related diseases. FEBS Lett doi: 10.1002/1873-3468.14995
  4. Luchkova A, Mata A and Cadenas S (2024) Nrf2 as a regulator of energy metabolism and mitochondrial function. FEBS Lett doi: 10.1002/1873-3468.14993
  5. Zakic T, Pekovic-Vaughan V, Cvoro A, Korac A, Jankovic A and Korac B (2023) Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue. FEBS Lett doi: 10.1002/1873-3468.14794
  6. Viña J and Borrás C (2024) Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan. FEBS Lett doi: 10.1002/1873-3468.14963
  7. Gallero S, Persson KW and Henríquez-Olguín C (2024) Unresolved questions in the regulation of skeletal muscle insulin action by reactive oxygen species. FEBS Lett doi: 10.1002/1873-3468.14937
  8. Santos M, Melo T, Maurício T, Ferreira H, Domingues P and Domingues R (2024) The non-enzymatic oxidation of phosphatidylethanolamine and phosphatidylserine and their intriguing role in inflammation dynamics and diseases. FEBS Lett doi: 10.1002/1873-3468.14992
  9. Delgado-Martín S and Martínez-Ruiz A (2024) The role of ferroptosis as a regulator of oxidative stress in the pathogenesis of ischemic stroke. FEBS Lett doi: 10.1002/1873-3468.14894
  10. Reis A, Rocha BS, Laranjinha J and de Freitas V (2024) Dietary (poly)phenols as modulators of the biophysical properties in endothelial cell membranes: its impact on nitric oxide bioavailability in hypertension. FEBS Lett doi: 10.1002/1873-3468.14812
  11. Paiva B, Laranjinha J and Rocha BS (2024) Do oral and gut microbiota communicate through redox pathways? A novel asset of the nitrate-nitrite-NO pathway. FEBS Lett doi: 10.1002/1873-3468.14859

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