Putting Glycosphingolipids in the Limelight

The latest "In the Limelight" issue of FEBS Open Bio is our largest ever, featuring eight Reviews and one Research article all centred on the topic of glycosphingolipids in human disease
Putting Glycosphingolipids in the Limelight

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The September issue of FEBS Open Bio puts the involvement of glycosphingolipids in disease in the limelight. Glycosphingolipids were once considered to play a purely structural role in cell membranes, but it has since become apparent that they play a key role in the nervous system and are associated with several diseases. Guest editor Sandro Sonnino introduces the contents of the issue in a fascinating interview conducted by Ioannis Tsagakis, starting with eight Review articles that focus on the role of glycosphingolipids in diseases as diverse as Parkinson's disease, cystic fibrosis, infertility, and parasite infections. We are also pleased to include an original research article by Robert Ledeen and colleagues, which reports that application of GM1, one of the major gangliosides of the central nervous system, can ameliorate memory and movement disorders in mice lacking both copies of the GM3 synthase gene.

We invite you to read the full issue here; the individual articles can also be accessed from the links below.

An open chat with… Sandro Sonnino

The relationship between depletion of brain GM1 ganglioside and Parkinson's disease

Glycolipids in Parkinson's disease: beyond neuronal function

Sphingolipid abnormalities in encephalomyeloradiculoneuropathy (EMRN) are associated with an anti-neutral glycolipid antibody

Glycosphingolipids within membrane contact sites influence their function as signaling hubs in neurodegenerative diseases

Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene

Glycosphingolipids in human parasites

Lipid rafts and human diseases: why we need to target gangliosides

Synthetic GM1 improves motor and memory dysfunctions in mice with monoallelic or biallelic disruption of GM3 synthase

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