In scientific research, collaboration and information sharing are pivotal for advancements. Repositories for scientific resources, like research tools and materials, provide critical support for the acceleration of scientific breakthroughs by supporting open science and fostering global collaboration among researchers. Addgene, a mission-driven non-profit repository for DNA-based tools, has grown into a vital resource for scientists to share and access materials and resources.

A Critical Mission

Addgene, established in 2004, operates with a simple yet profound objective: accelerate research and discovery by improving access to useful research materials and information. Through a repository of researcher-deposited materials, Addgene empowers scientists to access plasmids, viral vectors, and recombinant antibodies with ease. With its user-friendly platform and expansive catalog, Addgene has revolutionized the way scientists share and obtain plasmids, enhancing scientific sharing on a global scale.

An Extensive Repository

Addene’s plasmid repository includes over 125,000 plasmids, contributed by more than 5600 labs worldwide. These plasmids cover a broad range of applications such as CRISPR, optogenetics, biosensors, and more. The catalog also includes more than 700 ready-to-use AAV and lentivirus preparations and over 150 ready-to-use recombinant antibodies. Scientists can explore the repository, search for specific materials, and request samples for experiments through Addgene’s website.

A Novel Distribution Model

Addgene’s pipeline for plasmid distribution provides efficient processing, shipping, and delivery across the globe. Additionally, Addgene offers various services, including plasmid storage and viral packaging of select plasmids in the repository, to further support researchers' needs.

A Collaborative Community

Addgene fosters a vibrant and collaborative scientific community by encouraging scientists to share their plasmids. Researchers can deposit their plasmids in the repository, allowing others to benefit from their work by requesting their plasmids and promoting the open exchange of scientific knowledge. This culture of sharing reduces redundancy in research efforts, expedites the pace of scientific discovery, and enables researchers to build upon existing work more efficiently.

A Robust Library of Resources

As a long-time proponent of open science, Addgene makes all sequencing data available. The Addgene website includes a vast library of educational tools and resources, such as curated lists of commonly used vector backbones, CRISPR resources, and molecular biology basics. Additionally, there are protocols for basic molecular biology techniques, plasmid cloning, and working with viral particles. Addgene’s blog has a collection of posts on everything from 101 series for users new to antibodies, plasmids, and viral vectors to new tools available in the catalog. Additional knowledge is regularly shared through the Addgene YouTube channel, which contains webinars, protocols, and how-to guides, and the Addgene DataHub, which contains curated community-generated standardized reports describing experiments using Addgene materials.

Sharing Speeds Science

Addgene is an indispensable resource for the scientific community, playing a pivotal role in advancing scientific research through the sharing of DNA-based research materials. Addgene’s centralized platform for distribution promotes collaboration, accelerates discoveries, and enables researchers to focus on their core scientific inquiries. With its commitment to open science and dedication to supporting researchers worldwide, Addgene continues to be a driving force in the global scientific community, fueling innovation and transformative breakthroughs.

Top image by Addgene