My research interests focus on the roles mitochondria play in aspects of eukaryotic life, ranging from their origin, metabolism, biogenesis and role they play in cell death pathways. These are interrogated using biochemical, molecular biology, genetic and cell biology techniques. I incorporate these interests into classes I teach to provide an understanding of practical techniques and also the current literature in the field. I studied biochemistry at the University of Leeds, with an industrial placement at Astra Charnwood, followed by a PhD at the University of Bristol, supervised by Professor Andrew Halestrap, to characterise the molecular composition of the mitochondrial permeability transition pore, with support from MitoKor. My post-doctoral training on the mitochondrial pathway of apoptosis supervised by Dr Doug Green was at the La Jolla Institute of Allergy and Immunology in San Diego, California and St Jude Children's Research Hospital in Memphis, Tennessee. I then was an associate research scientist working in the laboratory of Professor Alexander Tzagoloff at Columbia University in New York to study biogenesis of mitochondrial cytochrome c oxidase in budding yeast, Saccharomyces cerevisiae. I held independent positions as assistant professor at the New York Institute of Technology in New York and Staffordshire University in Stoke-on-Trent where I continued my research and taught subjects related to biochemistry, cell biology, genetics and molecular biology. I am now a senior lecturer in biotechnology at Liverpool John Moores University. I am a strong supporter of scientific communications and outreach to disseminate scientific developments and knowledge to a broader audience with the goal of increasing the general support of the scientific process. I also direct Biomed News, a free biomedical research literature discovery platform that uses machine learning.
Mohamed Esmat
MSc. Cancer Biology — Medical Biochemistry & Molecular Biology at NCI, Cairo University
Cancer Biology & Immunology Researcher | MSc. Cancer Biology, National Cancer Institute, Cairo University
Interdisciplinary researcher working at the intersection of cancer biology, cancer immunology, molecular biology, and multi-omics. My research interests focus on T-cell biology, tumor–immune interactions, tumor microenvironment, immune cell plasticity, and molecular mechanisms shaping cancer progression and therapeutic response.
I combine computational analysis, literature-based research, and hypothesis-driven approaches to investigate regulatory mechanisms in cancer and immunity, with a growing focus on integrating these approaches with experimental cancer research.
I am also engaged in Open Science, preprints, open-source research tools, and community peer review, with an interest in reproducible and accessible biomedical research.