The MOlecular-Scale Biophysics Research Infrastructure (MOSBRI) enables ambitious integrative multi-technological studies of biological systems at the crucial intermediate level between atomic-resolution structural descriptions and cellular-scale observations. MOSBRI offers access to a range of services provided as free of charge transnational access (TNA). Physical and remote access to MOSBRI’s suite of instruments and methodologies are offered, as well as access to a range of pipelines that are integrated access to a synergistic set of biophysical instruments and technologies. Furthermore, products will be made available through virtual access. You can read more about MOSBRI’s TNA offers in the links below. Instruments/Methodologies Pipelines Products If you are unsure of what the best approach for characterizing your sample or system is, then we also offer Project maturation where the MOSBRI moderator panel experts will aid you in choosing the best access type and possible access site(s) for your project. In this case, only a description of the project has to be submitted.

My research activity has mainly concerned pyridoxal phosphate-dependent enzymes and vitamin B6 metabolism in bacteria and humans. Concerning PLP-dependent enzymes, I have dealt with their catalytic mechanism, catalytic promiscuity and evolution of catalytic activities, the design and experimentation of specific inhibitors, the mechanism of addition of PLP to apoenzymes and the folding mechanism. At the moment, I am mainly focused on the regulation of PLP biosynthesis and salvage pathways in bacteria and humans. In particular, I am interested in enzyme regulation mechanisms and transcriptional regulation, in the mechanism of PLP transfer to apoenzymes and in neurological disorders related to PLP metabolism. I teach Biochemistry, Biochemical Methods and Enzymology in Biological Sciences, Industrial Chemistry and Biotechnology courses at Sapienza University.