Genetic code: Mechanisms, Evolution and Engineering│26–28 March 2020│Strasbourg
The genetic code was unraveled some 55 years ago, in a short period of time, but through arduous and insightful chemical and biochemical experimental designs. Formally, the genetic code is a cypher, a frozen table of correlations between two sets of letters with few variations. Viewed at the molecular level, however, the code as we know it now appeared in stages, resulting from the complex molecular recognition and selection processes full of contingencies at the core of the transition from chemistry to biology in biological evolution. In the last twenty years, a wealth of structures of active ribosomes and components of the translation apparatus has appeared. We now have a rich diversity of structures at sufficient resolution to integrate biochemical and biological observations in congruence with molecular data.
In this meeting, these structural constraints will be described with their functional and organizational impacts on the cellular integration and homeostasis analyzed from various angles. Fifteen internationally renowned speakers, from four different European countries, have already accepted to present their last results. They will speak on four broad themes: ribosome structures and decoding, translational variations and miscoding, evolution and code optimization, ribosome engineering and code expansion. Topics will cover structures and kinetics of translation, neuronal translation, the interplay between translation and metabolism, the origins of the code and metabolism, and engineering of the code. Most importantly, twenty slots are kept for talks chosen from the received abstracts. This process will give the opportunity to speak to young scientists and allow for unexpected or recent new results to be presented and discussed. Two poster sessions are also planned to encourage exchange and discussions.
We are looking forward to meeting you in Strasbourg in March 2020.
Chair of the Scientific Committee
Professor emeritus - University of Strasbourg
Member of the French Academy of Sciences
Meeting website: https://decoding.sciencesconf.org/