This talk is an activity from the FEBS Junior Section, an initiative set up by students and young researchers from some of the FEBS Constituent Societies. Each month a Junior Section from one of the participant Societies organizes an online event on either a research or a career topic. This July talk is a research event organised by Biochemistry in Motion (BeM)/SEBBM Junior Consuls, the junior section of the Spanish Society for Biochemistry and Molecular Biology (SEBBM).
Speaker: Prof. Mara Dierssen, Center for Genomic Regulation of Barcelona
Topic: “The emerging scenario of epigenetic regulation in Down syndrome”
Time: 21 July 2022, 19:00 (CET)
For more information, see the presentation abstract below and visit Mara Dierssen's webpage.
Down syndrome (DS) is the most common genetic cause of intellectual disability. Even though great advances in the last decades have allowed better delineation of its pathogenetic mechanisms, its cellular and molecular bases are still poorly understood. Even though there is a clear contribution of the environment to the cognitive impairments of DS, the implication of epigenetic regulation mechanisms is still unknown. Long non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes in brain development and disease. Interestingly, lncRNAs are involved in learning and memory, they are critical for the adult hippocampal GABAergic circuit, and their association of with adult neurogenesis has been established, thus covering several of the DS pathogenicity mechanisms. We will discuss our new findings showing deregulated expression of lncRNAs in the hippocampus of a DS mouse model, the Ts65Dn, and their involvement in DS-specific neuropathology.
The FEBS Junior Section
Want to join this platform for young European life scientists? Learn more about our initiative, check out the Room for the FEBS Junior Section and – if you do not have a junior section yet – read this post about how to set one up!