Our interviewee is Mahima Bhat, PhD candidate at the University of Freiburg, Germany. Mahima received a FEBS Advanced Courses 60th Anniversary Award for best talk during the FEBS Advanced Course Protein Termini : From Insight to Impact 2024 (8–11 September 2024) in Oxford, United Kingdom.

Tell us about your research topic/work. What project(s) are you working on? What is the aim of your study?

My current research project for my PhD is focused on investigating the role of Methionine Aminopeptidases (METAPs) in breast cancer and exploring the therapeutic potential of co-targeting METAPs and phosphatidylinositol-3-kinase (PI3K).

The main objectives of my study are to identify potential combinatory therapeutic options for breast cancer treatment by targeting METAPs and PI3K, and to dissect the specific role of METAPs using advanced techniques and biochemistry. By delving into the importance of N-terminal processing by METAPs and exploring its potential for therapeutic purposes, we aim to provide valuable insights into the mechanisms underlying breast cancer progression and identify novel approaches for treatment.

Overall, the aim of my research is to generate data and evidence supporting the use of combinatory targeting strategies for breast cancer therapy, while also elucidating the mechanistic role of METAPs in mammalian cells. Through our work, we hope to contribute to the development of more effective and targeted treatments for breast cancer.

Who or what inspired you to choose a career in science?

My cousin, who is 15 years older than me, went to Paris to pursue her PhD upon receiving a scholarship when I was a teenager. This informed me about a career in science and research, which, combined with my deep interest in Science and Mathematics, inspired me to choose a career in science.

How did you learn about the FEBS Advanced Course? Why did you choose this course to attend?

I learned about the course from my PhD supervisor, who heard about it at a conference from a colleague.

How does attending this course influence your present and future plans? What are the benefits of attending the FEBS Advanced Course?

The Advanced Course on Protein Termini has been immensely beneficial in helping me connect with key figures in the field and gain an in-depth understanding of protein termini and their modifications. Attending this course has also provided me with valuable ideas for future research topics to pursue and insights into potential institutions where I can further my studies or collaborate on these topics.

What work were you presenting at the FEBS Advanced Course?

I presented my work on the function of methionine aminopeptidases, which are among the first and most important N-terminal modifying enzymes. I shared findings highlighting the critical role of these enzymes in cell survival and growth, along with preliminary data suggesting a potential link to ribosomal biogenesis.

How does it feel to receive a FEBS 60th Anniversary Award at a FEBS Advanced course as recognition for your work? How do you see this Award influencing your career and future?

It feels fantastic to be recognized for my work, and it definitely motivates me to continue pursuing my research. I believe this award will have a significant impact on my career, as it is a prestigious recognition. It will certainly strengthen my applications for future positions in the field after completing my PhD.

What is your advice to aspiring students/scientists?

My advice to aspiring students and scientists would be to believe in yourself. Don’t let failed experiments or setbacks discourage you. Perseverance is key! Science is one of the few fields that offers the opportunity to learn and grow every day. Embrace and enjoy the process!

Where do you envision the future of your career?

I envision the future of my career focused on leading a scientific group dedicated to protein biochemistry and its role in health and disease.

For more information on upcoming FEBS Advanced Courses and available travel grants, visit the FEBS website.

Photo by HI! ESTUDIO on Unsplash.