The GBM Compact conference will present impressive possibilities on how to study and manipulate biomolecular condensates and subcellular architecture, for example using modern imaging and biophysical techniques. These will allow researchers to study single molecules, nanoclusters or large assemblies and to understand their dynamics, material properties and functions in vitro and inside cells.

While the existence of membrane-less organelles, such as nucleoli, stress granules or Cajal bodies has been known for a long time, it has remained largely unclear how such organelles are actually formed, maintained and regulated. We now know that compartments can also be formed by the phase separation of proteins, RNA and DNA and combinations thereof. To investigate the newly emerging role of phase separation in biology, we need to develop new tools and approaches, as well as combine cell biology and biophysics with biochemical reconstitution, theory and modelling.

This meeting will bring together scientists from different disciplines which will synergistically decipher how novel functions and pathologies emerge from the process of phase separation in biological systems, and what molecular underpinnings facilitate and regulate this key process.

The meeting will start on Thursday, September 18 with the Fritz Lipmann Keynote Lecture by Michael Rosen (Department of Biophysics at UT Southwestern Medical Center and an Investigator of the Howard Hughes Medical Institute). The conference speakers will present impressive possibilities on how to study and manipulate biomolecular condensates and subcellular architecture, for example using modern imaging and biophysical techniques. In addition to excellent invited speakers, there will also be five slots for short talks selected from the submitted abstracts.
The poster exhibition and a get-together for all participants on the evening of the first conference day will round off the program. The best two posters will receive a poster prize (300 € each) at the end of the conference. 

More details are available here: https://gbm-compact.org/gbm-compact-2025.html