Our interviewee is Orsolya Németh-Szatmári, a PhD student at the Department of Biochemistry and Molecular Biology, University of Szeged, Hungary. Orsolya received a FEBS Open Bio Poster Prize at the ”Hungarian Molecular Life Sciences” conference in Eger, on 28–30 March 2025, for her work entitled ‘’Phase-separated ribosome-nascent chain complexes in stress response’’.
Tell us about your research topic/work. What project(s) are you working on? What is the aim of your study?
The focus of our research group's studies is on assemblysomes. The recently discovered assemblysomes form a distinct group of cytoplasmic, phase-separated, membraneless organelles (MLOs). Panasenko and colleagues identified Not1-containing granules that contain ribosome-associated nascent chains of the proteasomal subunits Rpt1 and Rpt2, which serve as the site for co-translational assembly of these proteins, and the name "Not1-containing assemblysomes" (NCAs) is derived from this finding. These cell components differ from other MLOs in several properties: their size is 100-200 nm, they can only be pelleted by ultracentrifugation, they are resistant to CHX (Cycloheximide) and EDTA, and they contain both the small and large subunits of the ribosome. The assemblysomes contain ribosomes stalled in translation, along with the associated mRNA molecules and nascent protein chains (disordered N-terminus protruding from the ribosome's exit tunnel). Our results suggest that assemblysomes form through phase separation, and we have demonstrated their evolutionary conservation as well as their role in DNA repair processes and in stress response. We are interested in investigating the relationship between assemblysomes and tumor resistance to therapeutic treatments, as our preliminary experiments suggest a potential link between these processes.
Who or what inspired you to choose a career in science?
Curiosity about biological mechanisms (especially cancer) and positive research experiences during my studies inspired me to pursue a career in science.
How does it feel to receive a FEBS Open Bio Poster Prize as recognition for your work? How do you see this Prize influencing your career and future plans?
I am deeply grateful to receive this Award, as it acknowledges not only my work but also the support and guidance I have received throughout my studies. It gives me confidence to continue my research and motivates me to further develop my scientific career.
What advice would you give to aspiring students/scientists?
Stay curious and do not be afraid to ask questions. Be patient with yourself, as research often involves setbacks, and view challenges as learning opportunities.
Where do you envision the future of your career?
I envision a research career where I can continuously grow and where my work brings real scientific and societal benefits.