Theresia Stradal - Cytoskeletal remodeling during infection: A tale of Salmonella et al.

Remodeling of the actin cytoskeleton is involved in all motile and membrane trafficking processes, including cell migration, phagocytosis, macropinocytosis, endocytosis, exocytosis, and last, not least autophagy. This explains why actin and actin polymerization regulators constitute prime targets of bacterial pathogens, which have evolved to manipulate signaling pathways to actin cytoskeleton remodeling at various key nodes, foremost upstream Rho GTPase signaling, but also downstream actin polymerization and depolymerization factors. In my talk, I will address the molecular mechanisms of host cell responses to well-characterized Salmonella enterica virulence factors, including members of the Sop (Salmonella outer protein) family of proteins translocated into the host, and from there move on to less well understood mediators of bacterial pathogenesis and effects.