Our interviewee is Adrian Zając, an Assistant Professor from the Institute of Biological Sciences, Maria Curie-Skłodowska University in Lublin, Poland. Adrian is a founding member of the Junior Section in Lublin and a member of the Junior Section in Poland, Polish Biochemical Society, FEBS Constituent Society.
What motivated you to pursue a career in science? Why did you choose this field?
Maybe it sounds shallow, but I was motivated to pursue a career in science because I’ve always had a deep sense of curiosity about how the world works. Even as a child, I constantly explored the world, and wanted to understand the reasons behind everyday phenomena. That early curiosity grew into a passion for discovering new knowledge and solving problems, which naturally led me toward science. I chose this field because it allows me to keep learning, stay curious, and contribute to making meaningful advancements.
Briefly introduce your research topic. What is the purpose of your research?
My research focuses on understanding the molecular mechanisms that determine the survival, resistance, and death of cancer cells, particularly human glioma cells. I investigate how key intracellular signaling pathways such as PI3K/Akt/mTOR, Ras/Raf/MEK/ERK, PLCγ1/PKC, and apoptosis-autophagy regulatory systems, based on a “molecular switch” Bcl-2:beclin-1 complex, influence the response of glioma cells to chemotherapeutic agents. A significant part of my work also explores how bioactive natural compounds, including fungal metabolites and plant-derived phytochemicals, can enhance the anticancer activity of targeted drugs.
What excites you most about your work or research?
The possibility of uncovering mechanisms that can genuinely improve treatment outcomes for patients with highly aggressive cancers like gliomas. Each experiment gives me the chance to understand a small piece of the complex signaling networks that determine whether cancer cells survive or die. And for sure, the most important, that science gives me a constant ability to learn and get knowledge.
Among all the scientific discoveries of all time, which is your favorite? Why?
That one I am working on now, because it seems to be a potential life and health improver nutritional supplement, however I can not tell the details so far due to patent procedure.
What do you do as a scientist to make your work interesting and accessible to the public?
As a scientist and, at the same time, an academic teacher, I focus on creating an engaging learning environment where complex scientific concepts become relatable and easier to understand. I use real examples from my research. This helps my students and society to see the relevance of what they are learning and encourages them to think critically.
I also incorporate interactive teaching methods, including discussions, case studies, and simple visual explanations, to help to grasp difficult molecular mechanisms. I encourage them to ask questions, explore their own ideas, and approach science with curiosity rather than intimidation.
By making my teaching clear, practical, and connected to real research, I aim not only to educate but also to inspire the next generation of scientists and to help them appreciate how scientific knowledge can translate into meaningful societal benefits.
What do you like to do in your spare time? Do you have hobbies?
If it is only possible, I love to read books, and also one day I'd love to write my own one.
How did you learn about the FEBS Junior Section? What motivated you to become a member?
I've learned it from my Polish Society and my local Branch. I wanted to become a member of this young society to make my networking better and to cooperate with others to share fresh ideas.
What is the importance of getting involved in FEBS JS activities for students and young scientists?
Getting involved in FEBS Junior Sections activities offers students and young scientists an invaluable opportunity to develop both scientifically and professionally. These activities create a supportive international community where early-career researchers can exchange ideas, learn from each other, and gain exposure to different research fields.
What advice would you give to aspiring students/scientists?
My main advice to aspiring students and young scientists is to stay curious and never stop asking questions. Curiosity is what leads to meaningful discoveries, so when something doesn’t make sense, lean into it. Follow your questions, read widely, and don’t be afraid to challenge assumptions. The goal isn’t to have all the answers right away, but to keep learning and improving how you think.
Where do you see your career going next?
In the next stage of my career, I aim to continue developing as an independent researcher while expanding my expertise in cancer biology and targeted therapies. I want to build on my current work by exploring new molecular mechanisms of drug resistance and identifying promising therapeutic combinations, especially those involving natural bioactive compounds.