Hif‐1alpha stabilisation is protective against infection in zebrafish comorbid models
Using comorbid zebrafish models of Mycobacterium marinum (Mm) infection and tailfin wound‐induced inflammation, we show that stabilisation of hypoxia‐inducible factor‐1α (Hif‐1α) is protective against systemic infection, despite comorbid inflammation leading to increased infection.
Using a local infection, we show that neutrophils distribute between infection and tailfin wound sites, but that Hif‐1α stabilisation caused neutrophils migration between the two sites to be reduced, increasing numbers at the infection.
Read the Original Article here: https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15433
Read the accompanying commentary here: https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15463
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